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Nat Commun 7:11321 Lukey MJ, Cluntun AA, Katt WP et al (2019) Liver-type glutaminase GLS2 is a druggable metabolic node in luminal-subtype breast cancer

Their binding triggers downstream signaling cascades and mediates the corresponding biological effects

Dexpanthenol (B5): Vital for fatty acid metabolism and using nutrients for fuel

This data suggests that CAFs are capable of shifting the metabolism of cancer cells from mitochondrial dependent to glycolytic dependent and upregulating their glutamine metabolism